Santa Monica College Peptide Based Biogenic Products in Dentistry Worksheet

​who, what, where(where is it going to be released), when(when can we use it), whyIntro: Peptide-based biogenic products have been recently introduced in dentistry to prevent
caries, promote remineralization, reduce dental hypersensitivity, and provide rapid relief.
History: It has long been recognized that fluoride is a naturally occurring mineral found in rocks,
soil, and water. Fluoride has been established in dentistry for several decades due to its
mechanism of action and ability to remineralize and strengthen the enamel to prevent or reverse
dental caries.
Target audience: Anti-fluoridation groups have preconceived misconceptions about the link
between fluoride usage and lower IQ levels or cancer risk. The use of peptide-based biogenic
dental products provides an alternative approach to remineralization for groups that are opposed
to the use of fluoride.
Mechanism of action: The peptides aggregate calcium and phosphate ions to facilitate the
remineralization process of the tooth structure. The peptide-based biogenic product is said to
come in the form of toothpaste, gels, solutions, and composites and is expected to be safe for use
by children and adults, The product deposits 10 to 50 micrometers of new enamel on the teeth
after each use.
Background: The process of demineralization occurs when bacteria metabolize sugar and
fermentable carbohydrates and as a result, produce acids that demineralize the tooth structure.
Objective: The objective of our research is to investigate the effectiveness of peptide-based
biogenic dental products and their potential for the product to be an alternative form of treatment
for individuals against the use of fluoride. Peptide-based biogenic products are emerging
technology that serves as valuable alternatives for tooth remineralization.
Hypothesis: Peptide-based biogenic products are equally as effective as fluoride and will
encourage people who are hesitant to use fluoride to be more open-minded to the idea of tooth
remineralization.
Goals:
– The peptide-based biogenic dental product is a useful and effective product that may be
utilized in a clinical setting. The peptide-based biogenic dental product could
revolutionize dental healthcare as a secure and efficient alternative to current procedures
and improve the health-related quality of life for the patient.
–
Peptide-Based Biogenic Products serve as a primary prevention method for caries
prevention by eliminating the need for traditional treatments such as restorations or
composite.
Benefits: Peptide-Based Biogenic Products have favorable qualities that include limited risk of
toxicity, the enhanced ability for the peptide integration into the enamel, and treatment of white
spot lesions after 30 days of application.
Limitations: However, Limitations include lack of availability and price. The conclusion
suggests that further research is needed to investigate the long-term effects of using biogenic
peptides in managing caries, (conclusion)but overall, these products have the potential to
provide a conservative approach to preserving tooth structure.
Controlled study: Alkilzy et al conducted a randomized control trial involving 70 children with
clinically visible cavities. The children were divided into two groups, one group was treated with
P11-4 in conjunction with fluoride varnish, and the control group was treated with only fluoride
varnish. After 3- 6 months the group that used peptide P11-4 in conjunction with fluoride varnish
showed a higher ability to remineralize tooth structure compared to the control group.