PHS 987 NEU Clinical Pharmacokinetic of An Investigational Compound Paper

PHS 987 Summer 2023 AssignmentThe data below are based on a clinical pharmacokinetic of an investigational compound
that was administered as an IV bolus dose (5 mg/kg). The table reports plasma and urine
data for the compound. Plots of these data are also provided on the second page.
Dataset and Information
Patient Body Weight = 62 Kg
Plasma Data
Cumulative Urinary Excretion
Time (hr)
Cp (ug/L)
Time (hr)
XU (mg)
0.5
600
4
9.8
1
570
8
16.4
2
510
16
23,6
3
475
24
26.8
4
430
36
28.6
6
350
8
288
12
194
18
100
Other Information About Drug
Binding in plasma: 90%
Blood: plasma ratio: 1.0
Assume that the patient is healthy
and has no renal/hepatic/cardiac
disease (GFR = 100 ml/min)
1. Calculate the total clearance, elimination half-life, and volume of Distribution of
the compound.
2. What is the fraction of the dose excreted by the kidney?
3. Calculate renal and hepatic clearance.
4. Is this compound extensively distributed in the body? Explain your answer.
5. Is the compound a “high clearance” compound? Explain your answer.
6. Calculate the renal excretion ratio. What is the “net” mechanism of excretion?