1800 words CASE STUDY ON DRUG TARGET VALIDATION

 Order Information: Drug Target Validation Case Study.  In this component, writer present the evidence for the proof of concept and validation of a drug target for a biologic. In this case this will be infliximab, the pathfinding biologic that has revolutionised the treatment of rheumatoid arthritis. This is based on a lecture and problem based learning session that has discussed the process toward the discovery of TNF as a molecule of major importance, and proof that its inhibition may be of benefit to rheumatoid arthritis patients, to the first clinical trial, and then the phase-II trial that finally proved the clinical efficacy. The writer should structure this according to the priorities they feel are important to the progress and success of the biologic, with headings. The study should be well presented, fit for showing to a future employer. The Study should: • Relate the progress of ideas as they occurred. • Present evidence from original and contemporaneous scientific papers with only essential reference to reviews and no reference to textbooks. • Use the Cite it Right referencing format. Using Endnote would be recommended. • Cover the discovery of TNF as a target relating to the classical stages of preclinical validation of a drug target, namely: o Is the target up-regulated in the appropriate disease state? o Is spatial and temporal expression consistent with the proposed role in the disease pathology? o Does removal or inhibition of the target ameliorate signs for which it is thought to be responsible? o Does increasing the activity of the target exacerbate signs for which it is thought responsible? o The report should not use these as titles or headings. Sections should be created according to the message the writer wishes to convey. • Evaluate the contribution animal models made to the discovery • Describe the design of the biological therapeutics cA2 and infliximab • Relate these to the proof of concept clinical trial for cA2, and the ATTRACT infliximab trial. Important objective for the writer- 1.identify the inflammatory disease in this case (arthritis) and the cytokinesis involved. 2.Role of the cytokinesis involved and the mode of action. e.g.cytokines-TNF alpha,IL-1 as a target 3.Can the target be identified and does it have a role in the disease. 4.Can the drug target be modified,optimising it . 5.Is the drug design development 6.Pre clinical and clinical developments (Phase I,PhaseII,PhaseIII) The citation style has to be in harvard references . We were instructed to prepare the case study as a scientist and the audience for this case study are scientist as well. It is very important to present graphs,tables and figures to support the evidence in each headingsThese graphs,tables and figures are from the published articles and not from the reviews.The maximum words should be 1000-1300 not more than that ,and these words are excluding the references ,graphs tables and figures.