genetic and epigenetic phenomena influence on cardiovascular risk by altering the pathophysiology of plasma lipoproteins

I need some assistance with these assignment. genetic and epigenetic phenomena influence on cardiovascular risk by altering the pathophysiology of plasma lipoproteins Thank you in advance for the help! Cardiovascular diseases are linked to a number of risk factors that contribute to their high incidence in industrialized countries, risks like elevated blood pressure, smoking, obesity, diabetes mellitus, metabolic syndrome, and dyslipidemia as one of the major factors that are contributing to cardiovascular morbidity and mortality (NCEP 2002). The prevalence of cardiovascular diseases is also increasing because of the trend of the aging of the population (Rayner and Petersen 2008). One of the most important risk factors for cardiovascular diseases is high cholesterol and saturated fat that is incorporated in significant amounts in the everyday diet (Emberson et al. 2003). Programs for saturated fat reduction in the diet in the general population has lead to significant improvement of cholesterol levels in the population of Finland for example, where the program for saturated fat reduction in every day’s diet leads to a significant reduction of the incidence of cardiovascular diseases (Laatikainen et al. 2005). The introduction of effective treatment of dyslipidemia is another factor that can significantly reduce the incidence of morbidity and mortality of cardiovascular diseases. Based on the data from World health organization 80 percents of all deaths due to cardiovascular diseases are concentrated in the low and middle income countries, and this is believed to be due to lack of access to effective medical care treatment, including effective programs for healthy diet and reducing saturated fat in the diet, but also due to lack of effective anti-hyperlipidemic drugs (WHO 2011). However, data from a number of studies show that the effectiveness of different statins is variable and influenced by genetic and environmental factors. Mounting pieces of evidence show that genetic variations influence the level of blood lipids within one individual, but also the personal diet has an important influence on the effectiveness of statins and other pharmaceuticals (Kajinami et al.

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