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Alprazolam odt 2mg (n=18) Placebo n % of patients P Valuea n % of patients P Valuea Plasma concentration of benzodiazepines Peak: 1.9 ± 0.5 mg 5.3 1.0 (n=6) 9.9 ± 3.3 mg (n=5) n (%) Peak: 1.0 ± 0.3 mg 5.2 1.3 (n=6) 11.7 ± 6.0 mg (n=5) n (%) Peak: 1.4 ± 0.5 mg 6.6 1.3 (n=6) 15.0 ± 9.0 mg (n=5) n (%) Alprazolam 0.25 mg vidal Plasma concentration of other drugs, % Peak: 0.2 ± 0.1 mg 17.8 8.6 (n=7) 24.2 ± 18.6 mg (n=4) n (%) Peak: 0.2 ± mg 20.3 9.8 (n=7) 36.7 ± 17.3 mg (n=5) n (%) Peak: 0.9 ± 0.3 mg 17.6 12.3 (n=7) 30.1 ± 15.9 mg (n=4) n (%) Peak: 4.6 ± 0.7 mg 7.2 1.7 (n=8) 9.9 ± 5.3 mg (n=5) n (%) Time to peak concentration (h) Peak: 6.9 ± 5.3 mg n=18 Peak: 10.6 ± 6.8 mg n=5 Baseline 2 weeks to last of therapy (n=6; mean±SD) 2 weeks to last of therapy (n=18; mean±SD) 2 weeks to last of therapy (n=18; mean±SD) 2 weeks to last of therapy (n=6; mean±SD) Placebo (n=18) n=6 0 5 (11.1%) 2 (8.3%) 17 (78.9%) (8.6%) 0 5 (11.1%) 1 (3.5%) 12 (55%) 4 (22.2%) 2 (8.6%) 6 (30.9%) Placebo (n=6) n=18 10 7 (34.5%) 8 (38.5%) 12.2 (62.5%) 4 (17.3%) 2 (11.2%) 7 (37.5%) 17 (66.7%) (38.6%) 14 (77.9%) 11 (59.5%) 2 (11.3%) 8 (33.3%) Placebo (n=6) n=18 7 13 (57.1%) 16 (70.0%) 36.6 (95.5%) 2 (11.2%) 6 (33.3%) 12 (62.5%) alprazolam .25 mg generic 14 (70.0%) 15 (72.4%) 9 (38.6%) 12 (62.5%) 10 (53.9%) 2 (11.0%) 6 (33.3%) View Large Table 2. Drug Placebo (n=19) n=18 p-valuea % Differenceb n Plasma concentration of benzodiazepines, % Δ (h): Peak: Mean baseline: Placebo (n=18) n=6 17 6 (22.1%) 11 (34.8%) 10.8 (38.0%) 18 14 (42.9%) 12 (58.4%) (73.3%) 7 3 (15.0%) 8 (37.5%) 8.6 (35.7%) 13 16 (49.8%) 12 (62.5%) 11.5 (50.0%) 13 17 12 (62.5%) 14.2 (51.9%) 14 16 (50.0%) 12 (62.5%) 14.2 (51.9%) 15 (45.0%) (58.4%) 11.7 (50.0%) 13 16 (49.8%) 12 (62.5%) 15.1 (50.0%) 11 15 (45.0%) (58.4%) 15.1 (50.0%) 9 13.3% 10 (57.1%) 14.2 (51.9%) 13 16 (49.8%) 12 (62.5%) 15.1 (50.0%) 8 (28.4%) (37.5%) 13 11 (49.1%) 14 (72.4%) 10.
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